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The major hazard with nasal-delivery decongestants, particularly long-acting forms is a cycle of dependency and rebound effects. The 12-hour brands pose a particular risk for this effect. This effect works in the following way:

  • With prolonged use (more than three to five days), nasal decongestants lose effectiveness and even cause swelling in the nasal passages.
  • The patient then increases the frequency of their dose. The congestion worsens and the patient responds with even more frequent doses, in some cases to as often as every hour.
  • Individuals then become dependent on them.

In 1985 it was noted that the number and severity of cases of rhinitis medicamentosum was increasing in proportion to the use of benzalkonium, an antibacterial preservative found in most on the shelf prepared saline nasal spray products. Rhinitis medicamentosum means that the nose gets stuffy and congested after use of nose drops such as oxymetazoline. The more the nose drops are used, the more rebound when the drug wears off, so that the drops become almost addicting and hard to stop. The >

Then it was discovered that you could get rhinitis medicamentosum just form the Benzalkonium alone, as well as saline with Benzalkonium. So, it wasn't the nasal

When you are allergic or with an infection, the chemicals can be more irritating "normal".

Recent articles on the negative effects of Benzalkonium include:
Berg: Mucosa exposed to benzalkonium chloride showed squamus cell metaplasia ( the normal cells changed to undesirable cells). Benzalkonium chloride appears to

Steinsvag: benzalkonium chloride has toxic effects on human respiratory mucosa and human neutrophils. It destroyed mucosa and inhibited human neutrophil action Benzalkonium chloride induces mucosal swelling, which explains why the presence of this preservative in a decongestant spray aggravates rhinitis medicamentosa.

Hoffman An irreversible cessation of ciliary movement was observed in ciliary cells exposed to nasal sprays containing Benzalkonium chloride As benzalkonium chloride can cause complete standstill of ciliary beat frequency in vitro in human nasal mucosa, we recommend that this preservative should not be used anymore in topical nasal medications.
SinuPhend nasal spray is made only from natural ingredients, providing fast relief from nasal congestion,